thissus the biggun
the video explainer:
uv
Veloclinic Blood Dope Simulator v3.1
(link for v 3.1 of the blood dope simulator where the blood equation was updated)
the basic premise of the blood dope simulator
is that:
GT performance is determined by how many watts
can be generated by the aerobic metabolism of carbohydrates
the limiting factor to metabolising carbohydrates
being
the availability of
Oxygen (O2)
more oxygen
=
more carbohydrate metabolized aerobically
=
more watts
each L of oxygen used per min
generates 5.05 kcal per min of energy
since 1 watt = 0.01433 kcal/min
each VO2 L/min = watts x 0.01433 (kcal/min)/ 5.05 kcal/L
from the total
watts @ VO2 max
given that threshold is between 82-90%
and
elite riders are 21-24% efficient
then
VO2 L/min = watts x 0.01433 (kcal/min)/ 5.05 kcal/L / {.21 to .24} (efficiency) / {.82 to .90} (percent @ threshold)
(big thanks to @scienceofsport on this equation)
EPO and blood doping work by
increasing VO2max by increasing Hgb mass:
this figure was generated by pulling data from studies that looked at
change in VO2 max
vs
change in Hgb mass (converted to gm/kg)
following EPO or blood transfusions
aside from one outlier
the results had remarkably similar slopes
of around 0.29
meaning
(Doped) VO2 L/min = (clean) VO2 L/min +(0.29 L/min/gm/kg x (Hgb doped gm/rider mass kg – Hgb baseline gm/rider mass kg)
or visually, example output from the simulator:
n since from above
VO2 L/min = watts x 0.01433 (kcal/min)/ 5.05 kcal/L / {.21 to .24} (efficiency) / {.82 to .90} (percent @ threshold)
when going from VO2 to watts:
the whole curve will be shifted up for:
higher efficiency riders
or
riders capable of riding at a greater percent uv VO2 max
at threshold
or down for:
lower efficiency riders
or
riders not capable of riding at a high perecent uv VO2 max
at threshold
now it’d be nice if all doping were created equal
but
it weren’t
stead:
for a given increase in Hgb mass
old school EPO will increase Hgb concentration
faster than Blood transfusion
(note the Blood slope was updated to 0.59 based on the Morkeberg 2008 study)
which will raise it faster than EPO micro dosing
because:
Old-school Standard (high dose) EPO
appears to have a diuretic effect
causing blood volume to decrease
whereas
EPO Micro dose
n
Blood transfusion
cause blood volume to expand
(interestingly the PRO simulation which is a best fit line from a real world former PRO whose regimen used fairly standard loading doses followed by lower maintenance doses appears to cause some diuretic effect but slightly less than the standard dosing)
which means:
in terms of biopassport risk
for a given increase in Hgb concentration
Micro dosing and Blood doping
will produce a larger increase in Hgb mass
than the Standard or PRO regimens
(with the caveat that
to get a Hgb mass increase greater than 10%
the doses aren’t going to be so Micro any more
or to get an increase of 10% quickly
Micro doses aren’t going to cut it
in contrast
continuing higher doses for extended periods
will lead to less diuretic effect
as the increase Hgb mass increases to a level were it
triggers an opposing volume expansion)
therefore:
in terms of biopassport risk
for a given increase in Hgb concentration
Micro dosing and Blood doping
will produce a larger increase in VO2 max
than the Standard or PRO regimens
and thereforefore:
in terms of biopassport risk
for a given increase in Hgb concentration
Micro dosing and Blood doping
will produce a larger increase in Watts/kg
than the Standard or PRO regimens
so in summary
from
a baseline
VO2 max
baseline
Hgb mass is calculated
which when given a baseline
Hgb concentration
baseline
blood volume is calcuated
similarly
given a baseline efficiency and and percent VO2max
at threshold
baseline
watts/kg at threshold is calculated
to simulate the effect of doping
a doped
Hgb concentraion is entered
the difference between the baseline and doped
Hgb concentration allows the calculation of
a doped Hgb mass
using the equation for each doping method
from the doped Hgb mass
the doped VO2max and ultimately
doped watts/kg is then calculated
for the citations n the like
http://veloclinic.tumblr.com/post/40824936108/phisiology-of-blood-doping
salvaged off the cache after cap’s exit
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